DUSP10 and viral infectious disease: This is illustrated by the observation that while the defect in T cell expansion seen on loss of DUSP10/MKP-5 is responsible for protection against EAE, this deficit does not result in a reduction in the numbers of LCMV-reactive T cells following viral infection, probably because of the compensatory effects of DUSP10/MKP-5 loss in stimulating APC function.