DUSP1 and Duchenne muscular dystrophy: DUSP1/MKP-1 has also been implicated in muscle regeneration as DUSP1−/− mice are impaired in their ability to recover from experimental muscle injury and, when crossed into a mouse model of Duchenne's muscular dystrophy (the mdx dystrophin null), they display exacerbated muscular dystrophinopathy [78].