However, glucocorticoids are known to upregulate DUSP1/MKP-1 expression [64] and not surprisingly dexamethasone effectively suppressed cisplatin-induced apoptosis in a lung adenocarcinoma cell line indicating that DUSP1/MKP-1 plays a key role in this potentially undesirable drug-drug interaction [65]. This evidence concerns the gene DUSP1 and lung adenocarcinoma.