Down-regulation of DUSP2 in acute myeloid leukemia (AML) is associated with constitutive ERK activation [90], while recent data from cancer genome sequencing of Diffuse Large B-cell lymphomas (DLBCL), the major form of non-Hodgkin's lymphoma, reveals that DUSP2 is one of the most frequently mutated genes in this disease [91,92]. The gene discussed is DUSP2; the disease is acute myeloid leukemia.