Finally, by suppressing p38 MAPK activity, DUSP1/MKP-1 has been reported to protect dopaminergic neurons from the toxic effects of 6-hydroxydopamine (6-OHDA) suggesting that strategies aimed at either increasing MKP-1 expression or activity might be a viable strategy in the treatment of Parkinson's disease [77]. This evidence concerns the gene DUSP1 and Parkinson disease.