The role of DUSP1/MKP-1 in mediating resistance to chemotherapy appears not to be restricted to cisplatin, as the ability of this phosphatase to inhibit JNK-mediated apoptosis has also been implicated in the resistance of pancreatic cancer cells to gemcitabine [66], multidrug resistance in glioblastoma [67], resistance to doxorubicin and taxanes in breast cancer [68] and resistance to the proteasome inhibitor bortezomib [69]. Here, DUSP1 is linked to familial pancreatic carcinoma.