SerpinB2 had previously been identified as a susceptibility gene in this model of skin carcinogenesis [129,130] and concomitant deletion of SerpinB2 reversed the sensitivity of DUSP5−/− mice to DMBA/TPA-induced papilloma formation identifying DUSP5 as a bona fide tumour suppressor by virtue of its ability to suppress SerpinB2 expression in this animal model of Ras-induced cancer [128]. The gene discussed is SERPINB2; the disease is papilloma.