DUSP7 and Infertility: These effects were judged to be secondary to a failure to dephosphorylate and inhibit protein kinase C isoforms, a prerequisite for the timely activation of Cdk1/CycB and are likely to be significant as both male and female mice lacking DUSP7/MKP-X have been reported as viable but infertile (http://www.mousephenotype.org/data/genes/MGI:2387100).