DUSP6 and neoplasm: In support of the idea that DUSP6/MKP-3 may be pro-oncogenic in certain cancer types DUSP6/MKP-3 is upregulated in human glioblastoma cell lines and mouse xenograft experiments showed that tumours arising from glioblastoma cells expressing DUSP6/MKP-3 grew significantly faster than non-expressing controls [167].