Overall, this strongly suggests that the IEC and the subsequent tumours were more proliferative in the absence of DUSP10/MKP-5 indicative of a tumour suppressor function for this MKP, an idea supported by the observation that higher levels of DUSP10/MKP-5 expression correlated with better survival amongst patients with colorectal cancer [193]. This evidence concerns the gene DUSP10 and colorectal cancer.