DUSP1 and Huntington disease: With respect to neurodegenerative disorders, DUSP1/MKP-1 has been reported to mediate neuroprotective effects in both in vitro and in vivo models of Huntington's disease through its ability to suppress polyglutamine-expanded huntingtin-induced activation of c-Jun N-terminal kinases (JNKs) and p38 MAPKs [76].