However, Phuchareon et al. recently identified the down-regulation of DUSP6/MKP-3 as a contributing factor to the reactivation of Ras-ERK signalling and drug resistance in epidermal growth factor receptor (EGFR) mutant lung cancer cell lines exposed to the TKI's gefitinib (Iressa) and erlotinib (Tarceva) [169]. Here, MAPK1 is linked to lung carcinoma.