FOXO3 and cancer: Purified VB1 is the most abundant vitexin compound in the EVn-50 mixture, and it has been found to inhibit growth and angiogenesis through suppression of the AKT/FOXO3 pathway in hepatocellular carcinoma [19], to suppress the growth of choriocarcinoma by inhibiting mTOR signaling [20] and to exert a broad-spectrum cytotoxic effect by arresting cancer cells at G2/M phase cell cycle in many cancers [21].