APP and amyloidosis: However, the percentage change of PET SUVR between baseline and + 6.3 months as a function of starting age in APP-SL70 mice showed an inverted U-shape for TSPO binding (quadratic fit, R = 0.69, p = 0.014, Fig. 2d) but a linear positive association for amyloidosis (linear fit, R = 0.50, p = 0.048, Fig. 2e).