BAP1 and non-small cell lung carcinoma: In human non-small cell lung carcinoma cells (H1299 cells) [32], BAP1 depletion negatively regulated the FoxK2-target genes MCM3, CDC14a, and CDKN1B. Although two of these (MCM3 and CDC14a) were targets of BAP1 binding in UM cells, we found no significant response in gene expression to BAP1 depletion.