In this subgroup, 10 patients (24%) had a clinically significant increase of [TIMP-2]·[IGFBP-7] (≥0.3) at 6 and/or 24 h after iodinated CM infusion; among those, 7 (70%) experienced a worsening of renal function within 72 h following iodinated CM infusion indicating possible CA-AKI. The gene discussed is TIMP2; the disease is acute kidney injury.