Among the subset of patients with an increase in [TIMP-2]·[IGFBP-7] considered clinically significant (≥0.3 at 6 or 24 h, n = 29 [38%]), we did not observe an association with possible CA-AKI, i.e., a subsequent worsening of renal function within 72 h of iodinated CM infusion defined according to the KDIGO classification [2, 18]. This evidence concerns the gene TIMP2 and acute kidney injury.