Conversely, among the 29 patients who had a significant (≥ 0.3) increase in [TIMP-2]·[IGFBP-7] 6 h and/or 24 h after CM infusion, 19 (66%) increased their KDIGO classification within 72 h (potential CA-AKI), a value close to the CA-AKI occurrence in the whole population of the study (55%). The gene discussed is TIMP2; the disease is acute kidney injury.