Change in [TIMP-2]·[IGFBP-7] was − 0.02 [− 0.14; 0.03] and 0.03 [− 0.11; 0.35] at 6 and 24 h among the 14 patients (18%) developing CA-AKI according to the creatinine criteria only. This evidence concerns the gene TIMP2 and acute kidney injury.