In unadjusted logistic regression models, being female (OR = 2.84), unmarried (OR = 1.63), regular alcohol consumer (OR = 5.47), former smoker (OR = 1.28), using insulin (OR = 1.3) and having poor glycaemic control (OR = 1.82) were associated with an increased odds of depression (Table 2). This evidence concerns the gene INS and major depressive disorder.