GPT and neoplasm: In multivariate analysis, the following variables remained significantly associated with presence of distant metastasis: an age < 62 years old (Odds ratio (OR) = 3.97; 95% Confidence interval (CI): 1.87–8.42; p < 0.001), male sex (OR = 2.79, 95% CI: 1.26–6.19; p = 0.011), a tumor size ≥4.0 cm (OR = 16.02, 95% CI: 5.31–48.30; p < 0.001), ALT level < 125 U/L (OR = 6.19, 95% CI: 2.26–16.92, p < 0.001), and a CA19–9 level ≥ 385 U/ml (OR = 3.53, 95% CI: 1.87–6.67; p < 0.001) (Table 3).