Pegilodecakin (PEGylated IL-10 or AM0010) monotherapy has been reported to achieve 25% objective tumor responses (ORR) in intermediate to poor risk renal cell cancer (RCC) in median 4th line of treatment (LOT) (range 1-8) (Naing A et al, JCO, 2016). Here, IL10 is linked to renal cell adenocarcinoma.