The dynamic response proteins included current and new exploratory checkpoint targets (PD-1, PDL-1, LAG-3, Gal-9, CD27, TNFR2) as well as, many proteins associated with the events that are hallmarks of immune response to cancer, such as cytokines/chemokines, angiogenesis, vascular cell adhesion and oncogenic signaling proteins. Here, LAG3 is linked to cancer.