MGC018 demonstrated favorable binding properties; potent cytotoxic activity toward multiple B7-H3-expressing human tumor cells in vitro; antitumor activity in B7-H3 human tumor xenografts (breast cancer, ovarian cancer, lung cancer and melanoma); a favorable tissue cross-reactivity profile across 34 normal human tissues; and acceptable safety following repeat-dose administration in cynomolgus monkeys. The gene discussed is CD276; the disease is neoplasm.