In this study the toxicity and efficacy of vaccination with irradiated autologous tumor cells in combination with a class B CpG oligodeoxynucleotide (CpG- B, CPG7909) and Granulocyte-macrophage colony-stimulating factor (GM-CSF) followed by systemic CpG-B and interferon-α (IFNα) administration was examined in patients with mRCC. This evidence concerns the gene IFNA2 and neoplasm.