The scores for activated T cells [(CD3+PD-1+) + (CD3+CD8+PD-1+)], activated cytotoxic T cells (CD3+CD8+PD-1+), and total macrophages [(CD68+PD-L1-)+ (CD68+PD-L1+)] in tumor tissue were directly correlated with clinical response (p values all < 0.05, Wilcoxon), and depth of response with the two CR pts having the highest degree of CD8+ T cell infiltration. The gene discussed is PDCD1; the disease is neoplasm.