Our hypothesis was confirmed with the observation that BXCL701, in combination with an anti-PD-1 antibody and NKTR-214 (a CD122-biased agonist) results in complete and durable response with functional demonstration of immunologic memory in a syngeneic mouse model of pancreatic cancer (Pan02) [1]. The gene discussed is PDCD1; the disease is pancreatic neoplasm.