GZMB and neoplasm: These cells have a distinct, pro-inflammatory phenotype; they are CD25highCD39low and secrete overt INFgamma, Granzyme A and Granzyme B. Further, this phenotype and the potency of T cells generated is dependent on the presence of B cells in the culture as the removal of B cells prior to treatment with CpG in culture yielded a cell product with a similar phenotype and anti-tumor efficacy to that of vehicle treated cells.