Since the nodal immune environment is influenced in part by tumor-derived factors, we tested a small cohort for cytoplasmic expression of IFN-gamma and IL-10 to explore the association between Th1 and Th2 status of the TILs along with the triple staining for the CD3+ T cells, CD20+ B cells and CD68+ macrophages in tumors and lymph nodes biopsies with clinical outcomes of breast cancer patients. This evidence concerns the gene IL10 and neoplasm.