Using melanoma cell line supernatants and co-cultures (employing a set of 5 melanoma cell lines encompassing various oncogenic mutations, including BRAFv600, PTEN, and NRAS), we found that enforced overexpression of constitutively active GKS3β (CA.GSK3β) rendered DC differentiation and maturation refractory to the suppressive effects of melanoma, which appeared to involve both soluble mediators and cell-cell contact. Here, PTEN is linked to melanoma.