Pharmacodynamic cohorts of patients with non-small cell lung cancer, head and neck squamous cell carcinoma (HNSCC) or colorectal cancer receiving 75 or 250 mg were evaluated for intratumoral CD8, FOXP3, GITR and tumoral PD-L1 expression by immunohistochemistry using matched biopsies from pretreatment and day 29. Here, TNFRSF18 is linked to head and neck squamous cell carcinoma.