CD4 and neoplasm: Preliminary analysis of the orthotopic TME of the checkpoint-resistant QPP8 line reveals no significant change in CD8 T cells, regulatory CD4 T cells (Treg), myeloid-derived suppressor cells (MDSCs), tumor associated macrophages (TAMs) and microglia infiltration, or CD8/Treg and CD8/MDSCs ratios with either CTLA-4 or PD-1 blockade (n=3-5).