Recently, we described AO-176, a next generation anti-CD47 antibody that blocks the CD47/SIRPα interaction, induces phagocytosis and causes a direct tumor cell-autonomous death while negligibly binding RBCs.Herein, we characterize the ability of our CD47 antibodies such as AO-176, to induce Immunogenic cell death (ICD) and Damage Associated Molecular Patterns (DAMPs) in tumor cells and to potentiate chemotherapy-induced ICD/DAMPs. Here, CD47 is linked to neoplasm.