VE800 treatment alone is sufficient to enhance the level of tumor infiltrating CD8 T cells in the MC38 model to a level comparable to anti-PD1 alone however the combination of VE800 and anti-PD1 promoted the highest level of tumor infiltrating CD8 T cells in the MC38 model as well as in the more aggressive B-raf Pten model. Here, PTEN is linked to neoplasm.