In this retrospective study, twenty-two patients with metastatic melanoma were treated with IL-2 18 Million IU/M2 intravenously over 15-30 minutes on days 1-3 and 21.6 Million IU/M2 intravenously over 15-30 minutes on day 5 on an outpatient basis. This evidence concerns the gene IL2 and metastatic melanoma.