The authors thank and acknowledge Eran Kotler and Moshe Oren for generously providing H1299-p53-mutant lines; Gigi Lozano, Florencia McAllister, Russell Broaddus, Stephanie Watowich, and Katy Rezvani for their valuable advice and insight; Sara Leahey, Soraya Zorro Manrique, Elien Doordjuin, and Weiyi Peng for their advice and support; and the University of Texas MD Anderson Cancer Center Pancreatic Cancer Moon Shot Program for their generous financial support of this project. This evidence concerns the gene TP53 and familial pancreatic carcinoma.