In tumor, paired biopsies showed ≥ 2-fold increased expression of PD-L1 and/or CD8+ T cell infiltration in 7/14 patients, with a 60% median reduction in OX40+FOXP3+ cells at doses of 1 and 3 mg/kg compared with doses <1 mg/kg. The gene discussed is TNFRSF4; the disease is neoplasm.