For example, while the density of CD8+ cells was 8-fold lower in tumor than stroma (150 vs 1200 cells/mm^2), those CD8+ cells were >4x more likely to be proliferating in tumor vs stroma (28% vs. 6%).To interrogate interactions across a whole section, we additionally developed a multispectral whole-slide scanning method, demonstrated on lung cancer using a subset of 7 stains from the 9-color panel above. The gene discussed is CD8A; the disease is lung carcinoma.