Our results demonstrate that in treatment naïve-NSCLC tumors, expression of PDL1 and other targetable immune markers correlate with expression of STING, EMT, smoking status and DDR pathway genes, and that treatment with cisplatin further enhances the immunogenicity of tumors through activation of the STING pathway in NSCLC cells. The gene discussed is CD274; the disease is non-small cell lung carcinoma.