In a hPD-L1-transduced MC38 tumor model treated with ALPN-202 or durvalumab, an approved PD-L1 inhibitor, anti-tumor responses were evaluated by serial tumor volume measurements, and intratumoral immune responses were assessed by RNA-Seq, flow cytometry, and immunoSEQ TCR repertoire analysis (Adaptive Biotechnologies). The gene discussed is CD274; the disease is neoplasm.