Noteworthy, PD-L1 expression was induced following vascular-targeted photodynamic treatment or ionizing radiotherapy through an increase in IFN-γ, then a mono- or combination treatment with systemic PD-1/PD-L1 pathway blockade inhibits the generation of potent local and systemic tumors in mouse models using human renal cells or murine colon cancer cells [31, 32]. Here, IFNG is linked to malignant colon neoplasm.