INSIG1 and Hyperglycemia: Based on the functions of Sgk1 and Insig1 in glucose transport and lipogenesis, we infer that the suppression of miR29c and induction of target genes in the liver, muscle and adipose tissue may alleviate the harmful effects of hyperglycemia and severe steatosis by promoting the transportation of blood glucose into these tissues and preventing lipogenesis at the end of the overfeeding period.