IgG1 and IgG3 subclasses contain proteins, which are usually mobilized against toxins (i.e., diptheria, tetanus) and viral proteins, through direct (antigen binding) or by mediating indirect effector functions, such as antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytotoxicity (CDC) [230]. This evidence concerns the gene IGHG3 and tetanus.