It was reported that caffeoylquinic acids in Ilex tea extracts were able to activate the pro-apoptotic factors caspase-3 and caspase-9 in TCA8113 cancer cells, and caspase-8 and caspase-3 in HT-29 human colon cancer cells, accompanied with the decreased expression of the inflammatory mediator NF-κB, which regulates cell proliferation, anti-apoptosis, and cell metastasis [6,85]. Here, CASP3 is linked to colonic neoplasm.