SPPL3 and asthma: Figure 5 shows the predicted pathways related to anti-asthma genes in OVA vs. saline and DSE vs. OVA. In OVA vs. saline, Vegfa was upregulated, whereas Kit, Acsl4, Hopx, Rps24, Errfi1, Gtf2e2, Ints6, 2310035C23Rik (KIAA1468) and Sppl3 were downregulated. Methylation changes were in the opposite direction from expression level changes, as shown in Figure 5A (bar plots next to genes).