The antibody used in our study does not distinguish between angiogenic and antiangiogenic VEGF; nevertheless, here, we demonstrated, for the first time, that multispecies probiotic supplementation could decrease VEGF serum levels in postmenopausal women with obesity in a dose-dependent manner; thus, studies including the usage of a VEGF165b antibody are needed to draw further conclusions. Here, VEGFA is linked to obesity due to melanocortin 4 receptor deficiency.