We confirmed that the bacterial prodigiosin promotes cancer cell apoptosis via up regulation of caspase-3, caspase-9, Bax, P53, AIF, PARP protein expression and down regulation of Bcl-2, XIAP and cIAP1&cIAP2 protein expression in JEG3 and PC3. The gene discussed is AIFM1; the disease is cancer.