These cytokines appear not to be related with depression differently from IL17A and IL-6, though we had predicted a reduction in anti-inflammatory cytokine IL-10 in the high depressive participants, as shown in an animal experiment: social stress on C57Bl/6J mice induces depression-like behavior, concomitant with the hypoproduction of IL-10 [27]. The gene discussed is IL6; the disease is major depressive disorder.