The analysis of transcriptomic data from 51 normal tissue types represented in the GTEx Portal database (n = 11,688) and all NB and LGG tumor samples from the TARGET and the TCGA databases (n = 153 and 508 respectively) demonstrated that PLK4 expression was low in almost all tissues, with 75% of them expressing ≤1.3 TPM (transcripts per million). This evidence concerns the gene PLK4 and neuroblastoma.