IL1B and Sepsis: Data on the role of vitamin D status and vitamin D supplementation in sepsis are also available both in pediatric and in adult patients: in pediatric patients a clear role for 25(OH)D3 and CAMP was not demonstrated [35], whereas in adults lower levels of 25(OH)D3 were found in sepsis [36] and a high-dose of vitamin D3 increases circulating CAMP and reduces inflammatory cytokines as IL-6 and IL-1β [37].