As shown in Table 3, in the stepwise forward Cox regression analysis, which included all the univariate predictors, NT-proBNP, NYHA class III, RRI > 75, heart rate > 70, MR, TAPSE ≤ 15 remained associated with the occurrence of primary end-point, but not age, diabetes, systolic arterial pressure, therapy with ACE-inhibitors/Angiotensin receptor blockers, therapy with beta-blockers, LVEF < 30%, tricuspid regurgitation, CVP > 5 mm Hg, GFR-EPI, presence of micro- or macroalbuminuria, hemoglobin. This evidence concerns the gene ACE and tricuspid valve insufficiency.