Interestingly, they found that, of the 80 circRNAs produced from the Ttn gene, some were dynamically regulated in DCM but not in HCM and their expression was dependent on the splicing factor RBM20, linking together the RBM20 function, circRNAs, and myocardial disease development [77]. This evidence concerns the gene RBM20 and familial dilated cardiomyopathy.