Among the numerous regulators of cancer metabolism, PGC-1α has been shown to regulate many processes linked to oncogenesis by, for example, promoting the expression of antioxidant genes which protect cells from the detrimental effects of ROS, enhancing the catabolism of glucose and fatty acids, and promoting gluconeogenesis and lipogenesis which perform opposite anabolic functions [166,167,168,169,170]. This evidence concerns the gene PPARGC1A and cancer.