Also, a beneficial effect of combined vitamin D and calcium on markers of glucose metabolism and lipid profiles in patients with type 2 diabetes mellitus [41] has previously been reported, but data on the effect of co-supplementation with vitamin D, vitamin K, magnesium, and zinc on markers of insulin metabolism and lipid profiles among vitamin D-deficient subjects with PCOS are still scarce. The gene discussed is INS; the disease is type 2 diabetes mellitus.