CREBBP and Werner syndrome: Li et al. (2010) identified six lysine acetylation sites (K366, K887, K1117, K1127, K1389 and K1413) in WRN, and these acetylation events were mediated by cyclic adenosine monophosphate (cAMP) response element binding (CREB)-binding protein (CBP) and p300 acetyltransferases after cellular exposure to the DNA cross-linking agent mitomycin c (MMC).