MAPK8 and Insulin resistance: Similarly, it is found that polyphenols lower insulin resistance by inhibiting PI3K/AkT and JNK of activation of the AMPK-SirT1-PGC1α axis (i.e., gingerol and anthocyans, and their ability to protect from diabetes and reduce insulin resistance using in vivo, ex vivo and in vitro studies [26,27,28,148,149,155].