The time taken for hypophysitis to appear varies depending on the ICPI used: it can be very early with combined treatments (30 days on average) (Scott et al. 2018), between 2 and 3 months (4 weeks up to 19 months) on anti-CTLA-4 (Dillard et al. 2010, Weber et al. 2012, Albarel et al. 2015, Joshi et al. 2016, Scott et al. 2018), and between 3 and 5 months on anti-PD-1/PD-L1 (Torino et al. 2013, Eigentler et al. 2016). The gene discussed is CD274; the disease is hypophysitis.