Exocrine pancreatic function has not been systematically explored, though it has been recently shown in one case of diabetes induced by nivolumab (anti-PD-1), with both a bi-hormonal deficiency (insulin and glucagon) and an exocrine pancreas insufficiency (asymptomatic reduction in fecal elastase) (Marchand et al. 2018). Here, INS is linked to diabetes mellitus.