Intact inhα/Tag mice develop gonadal tumors, but when prepubertally gonadectomized, adrenocortical tumors appear with a hyperplasia-adenoma-adenocarcinoma sequence and abundant LHCGR expression (Kananen et al. 1995, 1996, Rilianawati et al. 1998, Rahman et al. 2001, 2004, Bodek et al. 2005, Vuorenoja et al. 2007, 2008, 2009, Chrusciel et al. 2014, Doroszko et al. 2017a,b). This evidence concerns the gene LHCGR and adrenal cortex neoplasm.