SOD1 and amyotrophic lateral sclerosis: Mice expressing WT-SOD1 fused to yellow fluorescent protein (SOD1:YFP) age normally and show little or no evidence of WT-SOD1:YFP aggregation; whereas equivalently expressed fALS mutant G85R-SOD1:YFP produces clinical signs of ALS with evidence of mutant protein oligomerization, aggregation, and inclusion formation [48].