On further analysis, considering the interaction between CD4 count and CrAg titers, those with CD4 <50 cells/μL and titer ≥1:160 were at higher risk of meningitis or death (HR = 3.3; 95% CI: 1.1 to 9.8; P = 0.03) compared with those who had a CD4 >50 cells/μL and CrAg titer <1:160 (Fig. 4). Here, CD4 is linked to meningitis.