CD4 and infectious meningitis: In addition, the current WHO guidelines recommend lumbar puncture with cerebrospinal fluid (CSF) examination to exclude meningitis among asymptomatic CrAg+ patients where feasible.16 A randomized controlled trial among ART-naive persons with <200 CD4 cells/μL found that mortality was 28% [95% confidence interval (CI): 10% to 43%] lower among persons receiving CrAg screening and 4 ART adherence support home visits compared to those receiving standard of care.17 The attributable benefit of each of these interventions (CrAg screening vs home visits) could not be determined.