In addition, the current WHO guidelines recommend lumbar puncture with cerebrospinal fluid (CSF) examination to exclude meningitis among asymptomatic CrAg+ patients where feasible.16 A randomized controlled trial among ART-naive persons with <200 CD4 cells/μL found that mortality was 28% [95% confidence interval (CI): 10% to 43%] lower among persons receiving CrAg screening and 4 ART adherence support home visits compared to those receiving standard of care.17 The attributable benefit of each of these interventions (CrAg screening vs home visits) could not be determined. This evidence concerns the gene CD4 and meningitis.