In light of the discovery that mutations in FUS are ALS-causative, several groups carried out studies to determine whether the other two members of the FET family, TATA-Box Binding Protein Associated Factor 15 (TAF15) and EWS RNA Binding Protein 1 (EWSR1), have a role in ALS. The gene discussed is TAF15; the disease is amyotrophic lateral sclerosis.