Interestingly, the increasing evidence suggested that a relationship between cancer stem cells (CSCs) and angiogenesis exists in tumour microenvironment, called “crosstalk” which synergistically promotes tumour growth.3, 4, 91, 92 For example, Conigliaro et al49 demonstrated that CD90+ CSC like liver cells could influence epithelial cells by transferring exosomes. Here, THY1 is linked to neoplasm.