For example, it has been found that EMT reprogramming occurs in cancer cells after receiving miR‐223 from polymorphonuclear leucocyte‐derived exosomes.80 However, this impact of miR‐223 is transient because it is rapidly inactivated by the exonuclease XRN1, indicating that ectopic miRNAs and endogenous miRNAs act in different ways.80 In addition, MSC‐derived exosomes have been found to induce EMT in adjacent epithelial cells in many different cancers types.76, 77, 81, 82, 83, 84, 85, 86. The gene discussed is XRN1; the disease is cancer.