The underlying mechanism is that HCC‐derived exosomes result in overexpression of hepatocyte growth factor (HGF) in hepatoma cells and lead to subsequent c‐Met phosphorylation68 and downstream signalling pathways such as PI3K/Akt and MAPK/Erk activation.69, 70, 71, 72 Takahashi et al also found that sorafenib increases the expression of linc‐ROR, a stress response long non‐coding RNA, in HCC cells. The gene discussed is HGF; the disease is hepatocellular carcinoma.