VPS4A and hepatocellular carcinoma: Vps4, one of the compositions of ESCRT complex, is known as a multimeric mechanoenzyme with an ATP‐binding domain which binds to ESCRT‐III subunits then provides energy through dehydrating ATP to disassociate them from the cell membrane.10, 11, 12 Surprisingly, Wei et al13 found that the downregulation of Vps4 is an independent risk factor for recurrence‐free survival of hepatocellular carcinoma (HCC) patients.