LYNX1 and Alzheimer disease: In addition, Western blot analysis revealeda reduced Lynx1 expression in the cortex of AD modeling transgenic mice(3×Tg-AD) compared to wild-type mice [6].Based on these facts, we argue that Lynx1 plays animportant role in AD, and that the accumulation of Aβ1-42down-regulates the expression of this neuromodulator in the brain and disturbsthe Aβ1-42/ Lynx1 balance, causing α7-nAChR dysfunction.We studied the effect of Aβ1-42 on Lynx1 geneexpression in rat primary cortical and hippocampal neurons and evaluated theeffect of ws-Lynx1 and Aβ1-42 on LTP in mouse hippocampal slices.