Aβ1-42 in a 200 nMconcentration inhibits α7-nAChR, the most common nicotinic cholinergicreceptor in the brain; and the interaction between Aβ and the receptorleads to internalization of the latter in AD [1].In addition, Aβ inhibits the long-term potentiation(LTP) [2] that is a generally establishedmodel for the plasticity processes underlying memory and learning[3]. Here, CHRNA7 is linked to Alzheimer disease.