LTB4R2 and acute respiratory distress syndrome: Although the detailed roles of BLT2 in protection against ALI are unclear, we found that PLY treatment induced the production of large amounts of cysteinyl leukotrienes (CysLTs), and a CysLT1 receptor antagonist recovered PLY-induced mortality, vascular permeability, and airway resistance, in both WT and BLT2-deficient mice.