AICAR injections in HD mice led to improved cognition and coordination without extending survival in one study, but to increase apoptosis and accelerated death in another.14 Moreover, AMPK activation and nuclear translocation in the brain can lead to detrimental effects in HD,15 supporting the idea that stimulating mitochondrial biogenesis and the bioenergetics of the cells that are under a critical diseased situation, such as the alterations induced by mutant huntingtin, might not be the most optimal therapeutic option for this disorder. Here, HTT is linked to Huntington disease.