APPL2 and posterior cortical atrophy: Data from qPCR analysis demonstrated that APPL2, AMD1, NKX3.1, LTC4S, and TPD52 were significantly upregulated (p < 0.001), ALDH1A3 was downregulated (p < 0.001) while OAT did not show any significant difference in PCa versus normal cells (Fig. 2).