Several of the top-hit gene findings identified in our study have previously been associated with obesity-associated traits, and the significant CpG sites within or near the genes COX6A1P2/FGD2 (cg03957124), SBNO2 (cg18608055), RPS6KA2 (cg17501210), and SOCS3 (cg18181703) were all detected in a recent EWAS of adiposity20. The gene discussed is RPS6KA2; the disease is obesity due to melanocortin 4 receptor deficiency.