Further, five differentially methylated sites identified in our study – cg03957124 (COX6A1P2/ FGD2), cg18608055 (SBNO2), cg17501210 (RPS6KA2), cg18181703 (SOCS3), and cg06192883 (MYO5C) – have been associated with serum C-reactive protein (CRP) levels in a recent study52, confirming the link between obesity and inflammation. Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.