Mutations in further ED candidate genes TNF receptor associated factor 6 (TRAF6), Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Gamma (IKBKG, formerly NEMO), NFκB inhibitor α (NFKBIA) and NFκBs also cause immunodeficiency (Cui and Schlessinger 2006) but variants with effects on protein function were not identified in these candidates. This evidence concerns the gene IKBKG and immune system disorder.