TEK and neoplasm: The pro-angiogenic macrophages that are present in tumours are generally of the M2-like category, although they display a diversity not entirely reflective of the M1/M2 dichotomy and exist in subcategories such as the Tie2-expressing macrophages, which have been shown to be highly adept at promoting angiogenesis and other pro-tumour functions (Squadrito and De Palma, 2011).