KDR and neoplasm: Macrophages have been shown to drive tumour vascularisation in mouse models (Piaggio et al., 2016; De Palma et al., 2003; Lin et al., 2006) and the depletion of tumour-associated macrophages results in an improved response to drugs targeting the VEGFR pathway, suggesting that macrophages aid in the escape from VEGFR inhibition (Shojaei et al., 2009; Zhang et al., 2010).