Some comorbid conditions other than diabetes mellitus such as renal scars, nephrotic syndrome, focal segmental glomerulosclerosis, pancreatic cancer and chronic kidney failure may also affect urine MMP2 and MMP9, TIMP1 and TIMP2 and TGF-β1 concentrations (28,29,30,31,32,33). This evidence concerns the gene TIMP2 and nephrotic syndrome.