Consequently, we compared the methylation profiles of K27M-mutated diffuse midline gliomas (including DIPG) to G34R-mutated tumors and well-characterized supratentorial tumors without mutation in histone H3 genes, i.e. MYCN and PDGFRA tumor subgroups (Fig. 2a, Table 2) [15]. Here, MYCN is linked to diffuse intrinsic pontine glioma.