For instance, Wei et al. [17] compared the expression levels of serum CA125 and HE4 in 158 individuals, including 64 patients with ovarian cancer, 64 with ovarian benign tumors, and 30 healthy individuals, and reported high sensitivity and specificity of HE4 (75% and 98%, respectively) for the diagnosis of ovarian cancer. This evidence concerns the gene WFDC2 and ovarian benign neoplasm.