The possible involvement of coenzyme Q10 (CoQ) deficiency or impaired GGPP-related prenylation has been reported in several cell lines, such as myocytes, hepatocytes, or tumor cells, as the underlying mechanism of HMGCR inhibition-induced apoptosis (Alizadeh et al., 2017, Auer et al., 2016, Demierre et al., 2005, Tavintharan et al., 2007). This evidence concerns the gene HMGCR and neoplasm.