INSR and lipodystrophy: Furthermore, these lipodystrophy-related metabolic changes have also been confirmed in different lipodystrophic mouse models, such as the A-ZIP/F1 mouse, which is the typical fatless mouse model (Moitra et al., 1998), or in mice with double knockout for insulin receptor and insulin-like growth factor 1 (Boucher et al., 2016, Softic et al., 2016).