POLG2 and Hypercalciuria: Renal calcification is often associated with metabolic abnormalities including hypercalciuria, and we therefore performed biochemical analyses of plasma and urine samples from WT (Polg2+/+) and heterozygous mutant Polg2 (Polg2+/Y265X) mice.2, 4, 6, 7Polg2+/Y265X mice were fertile, grew at similar rates as their Polg2+/+ littermates, had similar body weights (data not shown), and appeared morphologically normal.