In the case of neurodegenerative diseases such as AD, PD, and HD, degenerating neurites observed in brain tissue samples display increased levels of autophagy-related vesicular compartments [16] and in LRRK2 PD models, stimulating autophagy can exacerbate the dendritic retraction that may occur via excessive mitochondrial breakdown [63]. The gene discussed is LRRK2; the disease is Parkinson disease.