OAS1 and hand, foot and mouth disease: In 2014, Cai et al. tested four single-nucleotide polymorphisms (SNPs) [2'-5'-oligoadenylate synthetase 1 (OAS1) rs10774671, PSGL-1 rs2228315, SCARB2 rs41284767 and IL28B rs12979860] in 333 HFMD samples and 163 control samples [30].