PGF and urethra adenocarcinoma: A potential model combining baseline care with PlGF/sFlt-1 ratio and Middle Cerebral Artery Doppler/UAD-Free RI ratio did demonstrate statistical significance over baseline care (ROC area 0.76, p = 0.016) but was rejected due to significant risk of over-fitting (44 adverse pregnancy outcomes in N = 189 cases) and did not demonstrate superiority over Model A (p = 0.45).