Recently, various mutations of BAP1 have been found in several tumors, including uveal melanoma (UM) [4], mesothelioma [5], renal cell carcinoma (RCC) [6, 7], and intrahepatic cholangiocarcinoma (ICC) [8, 9], but the frequency of BAP1 mutations varies widely among different tumor types. The gene discussed is BAP1; the disease is mesothelioma.