As identified by MS (Table 2), proteins such as complement inhibitory factor H (gi|15485713, spot 2) and alpha-1-inhibitor III (gi|83816939, spot 3) were found upregulated in the T2D sample pool whereas proteins such as murinoglobulin 1 (gi|12831225, spot 1) and transferrin (gi|61556986, spot 4 and gi|1854476, spot 5) were down regulated in the T2D sample pool. Here, TF is linked to type 2 diabetes mellitus.