As identified by MS (Table 2), some albumin cognates (gi|158138568, spots 1–5) and transthyretin (TTR; gi|136467, spot 7) were found exclusively in the control sample pool, whereas vitamin D-binding protein (DBP) precursor was downregulated in the T2D sample pool (gi|203941, spot 6). Here, TTR is linked to type 2 diabetes mellitus.