The S100 family of calcium‐binding cytosolic proteins, comprising 25 known members,34, 35 has been postulated to regulate various cellular processes, including channel dynamics, cytoskeletal assembly, calcium balance, cell apoptosis, migration, proliferation, differentiation, inflammation and energy metabolism.21, 36, 37, 38, 39 Among these, S100A10 is widely expressed in numerous different types of human cancer, including lung adenocarcinoma, ovarian cancer and colorectal cancer.9, 10, 11, 40, 41 In this study, we further demonstrated that S100A10 is overexpressed in human GC tissues. This evidence concerns the gene S100A10 and colorectal cancer.