As a plasminogen receptor, S100A10 is thought to play an important role in tumour invasiveness, angiogenesis, and tumour metastasis.42, 43, 44 Consistent with this, we found strong S100A10 expression in metastatic lymph nodes of GC patients, suggesting that S100A10 may promote GC metastasis. This evidence concerns the gene S100A10 and gastric cancer.