ANXA2 and gastric cancer: Ubiquitylation plays a crucial role in S100A10 degradation, and its binding partner, annexin A2, regulates its polyubiquitination and degradation.31, 45 In fact, mass spectrometry data from other studies have indicated that K47 of S100A10 is able to be ubiquitylated.46, 47 Our current results show that S100A10 is succinylated at K47, and this modification is more prevalent in GC tissues than in normal tissues.