S100A10 and cancer: Its widespread up‐regulation in cancer is in part due to transcriptional activation.12 Alone, the S100A10 protein is unstable, and its association with annexin A2 protects S100A10 from ubiquitin‐dependent proteolysis.31 This also suggests that the regulation of S100A10 at the protein level may be more common than its regulation at the gene level.