verify that the loss of insulin growth factor binding protein‐7 expressed by tumour associated endothelial cells (TAEs) induces the tumourigenesis and invasion of tumours through activating FGF4‐FGFR1‐ E26 transformation specific (ETS)2 pathway.86 TAEs are also associated with tumour angiogenesis. Here, FGFR1 is linked to neoplasm.