In accordance to previous research, Hu MH and colleagues have verified that SC‐43 (a sorafenib derivative) induced the apoptosis and death of CCA cells through enhancing SH2 domain‐containing phosphatase 1 (SHP‐1) activity which leads to phosphorylation STAT3 and downregulates cyclin B1 and Cdc2.129 TAMs promote CCA angiogenesis and assist extracellular matrix decomposition and reconstruction to enhance tumour invasion and growth by expressing MMP‐9 and communicating with CCA cells. This evidence concerns the gene MMP9 and cholangiocarcinoma.