GSK3B and cholangiocarcinoma: Wnt/β‐catenin signalling pathway is one of the significant signalling networks that induces tumourigenesis and tumour progression in CCA.9, 10 WNT protein, a type of secreted glycoprotein expressed by Wnt gene, binds to the Frizzled family receptors on cell membrane to activate Dishevelled (DVL), which then inhibits the activity of the complex made up of axin, adenomatous polyposis coli tumour suppressor protein (APC) and glycogen synthase kinase (GSK)‐3β and suppresses β‐catenin phosphorylation.