And anti‐VEGFs treatment plays an important role in the treatment of CCA.53 VEGF‐D regulates the activities of stromal cells and tumour cells in tumour lymphatic metastasis by binding to lymphatic growth factor receptor (VEGFR)‐3.54 Similarly, VEGF‐C induces lymphatic invasion and metastasis in intrahepatic CCA by the preexisting lymphatic vessels in the tumour margin.55 Jinqiang Zhang and colleagues verified that miR‐101 restrains transcription and translation of VEGF genes and the low expression of VEGF inhibits CCA angiogenesis.56 Here, FLT4 is linked to cholangiocarcinoma.