The accumulated unphosphorylated β‐catenin in the cytoplasm can enter the nucleus and combine with TCF/LEF transcription factors to regulate the expression of oncogenes involved in CCA tumourigenesis, proliferation, and drug resistance like cyclin D1 and c‐Myc.11, 12, 13 In support of the notion that Wnt signalling promotes CCA tumourigenesis, Liu et al. The gene discussed is HNF4A; the disease is cholangiocarcinoma.